Neurofilament Light Chain Concentration in the Prediction of Treatment Response in Multiple Sclerosis

N Moradi; S Sharmin; CB Malpas; J Kuhle; P Benkert; D Leppert; EK Havrdová; D Horáková; P Kleinová; T Uher; A Manouchehrinia; J Hillert; T Olsson; I Kochum; BV Taylor; M Barnett; TJ Kilpatrick; K Buzzard; T Kalincik

Journal article

Neurofilament Light Chain Concentration in the Prediction of Treatment Response in Multiple Sclerosis

N Moradi, S Sharmin, CB Malpas, J Kuhle, P Benkert, D Leppert, EK Havrdová, D Horáková, P Kleinová, T Uher, A Manouchehrinia, J Hillert, T Olsson, I Kochum, BV Taylor, M Barnett, TJ Kilpatrick, K Buzzard, T Kalincik

European Journal of Neurology | Wiley | Published : 2026

DOI: 10.1111/ene.70505

Abstract

Introduction: Management of multiple sclerosis (MS) revolves around timely initiation of effective disease-modifying therapy. Here we investigate the additive predictive value of age-adjusted normalised neurofilament light chain (NfL) concentrations when combined with a clinicodemographic model of treatment response. Methods: Data were obtained from three sources: the University Hospital Basel, the SET cohort in Prague, and EIMS and IMSE cohorts from Sweden. NfL samples were collected within 90 days of baseline, age-adjusted and normalised using a reference population. Principal component analysis reduced the dimensionality of clinicodemographic predictors. Cox proportional hazards models es..

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